Two Hundred Years of Cancer Research英文资料.pdfVIP

T h e n e w e ngl a nd j o u r na l o f m e dic i n e anniversary article Two Hundred Years of Cancer Research Vincent T. DeVita, Jr., M.D., and Steven A. Rosenberg, M.D., Ph.D. n the 200 years since the New England Journal of Medicine was founded, From the Yale Comprehensive Cancer cancer has gone from a black box to a blueprint. During the first century of the Center and Smilow Cancer Hospital at IJournal ’s publication, medical practitioners could observe tumors, weigh them, Yale–New Haven, Yale University School of Medicine, and Yale University School and measure them but had few tools to examine the workings within the cancer of Public Health — all in New Haven, CT cell. A few astute observers were ahead of their time, including Rudolf Virchow, who (V.T.D.); the National Cancer Institute, National Institutes of Health, and the 1 with the benefit of a microscope deduced the cellular origin of cancer in 1863, and Uniformed Services University of the Stephen Paget, who in 1889 wisely mused about the seed-and-soil hypothesis of Health Sciences School of Medicine — 2 all in Bethesda, MD (S.A.R.); and George metastatic disease, a theory that is coming into its own today (Table 1). Other key