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安胃汤对胃溃疡鼠胃粘膜FasFasL表达的影响
目 录
中文摘要 ················································1
英文摘要 ················································3
引 言 ················································5
正 文 ················································7
1. 实验材料和方法··········································7
1.1 实验材料 ··············································7
1.1.1 动物 ·················································7
1.1.2 药物与试剂···········································7
1.1.3 主要仪器设备 ·········································7
1.2 实验方法··············································7
1.2.1 实验动物分组 ·········································7
1.2.2 实验性大鼠胃溃疡模型的制备···························8
1.2.3 给药 ·················································8
1.2.4 标本采集及处理 ·······································9
1.2.5 溃疡指数的测量和计算 ·································9
1.2.6 HE染色方法 ·········································10
1.2.7 再生粘膜厚度、粘膜肌层缺损度的测定 ··················10
1.2.8 S-P免疫组化染色方法及结果判定 ·······················10
1.2.9 统计学方法 ··········································11
2. 实验结果···············································11
2.1 动物外观观察 ·········································11
2.2 胃窦大体形态观察·····································11
2.3 各组溃疡指数的比较 ···································11
2.4 HE 染色的组织形态结构观察 ·····························12
2.5 各组再生粘膜厚度、粘膜肌层缺损度的比较 ················12
2.6 免疫组织化学染色结果的观察 ···························13
3. 讨 论 ················································15
3.1 现代医学对消化性溃疡的认识 ···························15
3.2 现代医学治疗消化性溃疡的对策及现状 ···················17
3.2.1 临床上常用的抑制胃酸分泌的药物 ······················17
3.2.2 抗HP 感染治疗 ······································18
3.2.3 胃粘膜保护剂········································19
3.3 关于Fas/FasL 的讨论···································20
3.3.1 Fas 、FasL 概述 ·······································20
3.3.2 Fas/FasL 在胃癌发生发展中的作用机制 ··················21
3.3.3 Fas/FasL 胃溃疡
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