调补五脏方对肺肾气虚型copd稳定期外周血t淋巴细胞亚群、bode指数及生活质量的影响.pdf

f删f炒炒 目录 要·······························-·······································…···…·······1 要·····“…”“““··“““““”．．”“”””···································…····．3 。。。。‘’。‘。‘。。。。。。。。。。。‘‘。‘。。。。。。。。‘。。。。。。。’’。’‘。。‘。‘。。’。。‘·································5 方法·········…·································……·········……····…··……．．．7 。。。‘‘‘‘。。。‘‘。。。’。’。。。‘。。’。’’。‘’。。‘’’。‘。‘。’。。’。。。。。。。。‘·····················000············16 ””“…一””……一“……”“一“……一””“””””“”””””““””””“…28 展望·································…···································…·······…29 献········································…··················……···…············．．30 。‘。。。‘‘。。。‘。’。。。。。。。。。‘。。。。。。’。。。。。。‘。。。···。··············································35 。‘。‘‘。。。‘‘‘‘‘。‘。‘。‘。‘。‘。。‘。‘。‘‘。。。。。‘。。。。。。。‘。‘‘‘·········································36 述············································································…········41 历···········································································…·········46 群、BODE指数及生活质量的影响 韩林华 中文摘要 目的： 采用随机对照的设计方案，根据五脏相关理论，运用调补五脏方治疗肺脾肾气虚型慢性 阻塞性肺疾病稳定期患者，通过观察治疗前后患者临床症状、体征、外周血T淋巴细胞亚群 虚型慢性阻塞性肺疾病稳定期的疗效。 方法： 将60例中医辨证属肺脾肾气虚型慢性阻塞性肺疾病稳定期病情分级为II一Ⅲ级的患者随 机分为治疗组和对照组。对照组给予西医常规治疗，治疗组在西医常规治疗基础上加服调补 五脏方，疗程均为3个月，治疗前后比较两组临床症状、体征、疗效、外周血T淋巴细胞亚 群(CD4+、CD8+、CD4+／cD8+)、BODE指数及生存质量影响。 结果： 1．两组临床证候及疗效比较：治疗组治疗后临床症状和体征均较治疗前有显著改善 (PO．05)；而对照组除咳嗽、咳痰、喘息、气短等症状和体征较治疗前有显著改善外，其余 治疗组的治疗效果优于对照组。 (PO．05)。表明治疗组较对照组有更显著的提高患者免疫功能的作用。 3．两组BODE指数比较：治疗组治疗后各项指标及总分均较治疗前有显著性差异 两组比较，治疗组在体重指数上较对照组有显著性差异(PO．05)，其余各项指数及总分均无 显著性差异(PO．05)。表明治疗组能显著的改善患者的营养状况。 日常生活评分、社会活动评分较治疗前有显著差异(PO．05)，其余各项评分及总分平均分值 无明显差异(P0．05)；两组间相比较，治疗组各项评分及总分平均分值与对照组相比，均有 显著差异(PO．05)。表明治疗组对于改善患者的生存质量，尤其在抗抑郁和焦虑方面，较单 纯使用西医的对照组具有显著优势。 结论： 调补五脏方配合西医常规治疗中医辨证属肺脾肾气虚型的慢性阻塞性肺疾病稳定期患 者，同单纯的西药组相比，可以更好地改善患者的临床症状、体征，提高患者免疫功能，改 善营养状况，提高患者的生存质量。 关键词：五脏相关；调补五脏方；慢性阻塞性肺疾病；T淋巴