感染性心内膜炎PPT课件.pptVIP

7/98 Update onInfective Endocarditis Larry Baddour, MD University of Tennessee Pathogenesis Disruption of the endocardial layer as a complication of abnormal blood flow associated with underlying cardiac defect Bacterium-endothelium interaction with bacterial attachment and invasion of endothelial cells Epidemiology Underlying valvular abnormality predisposing to infective endocarditis rheumatic fevera common cause in the past mitral valve prolapsecurrently represents the most common underlying cardiac abnormality mitral valve prolapse risk for infective ednocarditis is ?5x-8x mitral reg