ICU侵袭性真菌感染诊治对策摘要.ppt

GI tract GI tract Model for Invasive CandidiasisBlijlevens, Donnelly, De Pauw. Brit J Haematol 2002;117:259-64 insult injury translocation infection antibiotics selection Normal commensal flora Disease Central venous catheter Candida species GI tract Lancet Infect Dis. 2003. 3: 685-702 Nat Rev Microbiol. 2013. 10(2):112-122 Nat Rev Microbiol. 2013. 10(2):112-122 念珠菌来源 外源性：导管位置、导管护理 内源性：胃肠粘膜保护、肠内营养 定植 高负荷定植 感染 提 要 ICU与感染 危重病人侵袭性真菌感染 念珠菌来源 抗真菌药物及选择 关于氟康唑 系统性抗真菌药：全球 isavuconazole ravuconazole fluconazole itraconazole posaconazole L-AMB ABCD ABLC voriconazole caspofungin micafungin anidulafung