蔓荆子化学成分及含量测定方法的研究.pdfVIP

Studies on the Chemical Constituents and Dtermination Method of Viticis Fructus Speciality: Chinese Materia Medica Author: Guan Ren-jun Tutor: Yu Zong-yuan Abstract Viticis Fructus (Mangjingzi in chinese name) is a traditional chinese medicine Vitex trifolia prepared from the fruit of L. It has been recorded in Chinese Pharmacopoeia as a folk medicine. According to the theory of chinese medicine, Viticis Fructus has the funtion of Dispersing wind-heat and Removing heat for treating head and ocular disease, which has been used in the treatment of headache, cold, cancer, migraine, eyepain and rheumatism. For future reasonable development and application, we have systematically studied on the chemical constituents and determination methods of Vicitis Fructus. Our research results are as follows. 1. Literature review According to the study purpose, conducted a literature review relating to the source, chemical constituents, pharmacological effect, Processing Technique, quality of Vicistis Fructus. 2. Study on chemical constituents in fruits of Viticis Fructus. In this thesis, the chemical constituents of the extracts with 95% ethanol from Viticis Fructus were studied. 12 compounds were isolated with slica gel, high-spee d counter-current chromatography, etc. On the basis of analysis NMR, MS and mea suring of physic-chemical characters, 11 chemical structure were elucidated as castic in(I), artemetin(II),5,7,3,4-tetrahydroxy-flavone6-C-β-D-glucopyranoside(III), 3,4-dihydr ox-ybenzoic(IV), 4-hydroxybenzoic(V), 3,6,7-trimethylquerce