青蒿素的合成生物学研究进展孔建强.pdf

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青蒿素的合成生物学研究进展孔建强.pdf

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Acta Pharmaceutica Sinica 2013, 48 (2): 193−205 193 * , , , (, , , 100050) : , , , , -4, 11-P450 , : ; ; ; ; : R931 : A : 0513-4870 (2013) 02-0193-13 Research progresses in synthetic biology of artemisinin * KONG Jian-qiang , WANG Wei, CHENG Ke-di, ZHU Ping (State Key Laboratory of Bioactive Substance and Function of Natural Medicines Key Laboratory of Biosynthesis of Natural Products, Ministry of Health of PRC, Institute of Materia Medica, Chinese Academy of Medical Sciences Peking Union Medical College, Beijing 100050, China) Abstract : The first-line drug artemisinin is widely used against malaria. Commercially available artemisinin is extracted from plants. However, the lack of sufficient raw material, artemisinin and the cost associated with the drug’s manufacture have limited the supply of ACT to most malaria sufferers in the Developing World. As such, it is important to develop a low cost, fine to environment and high-quality method to supply sufficient and reliable quantities of artemisinin in the future. The field of synthetic biology, which utilizes cell factories to mani