海洋天然产物化学的研究新进展.pdfVIP

1212 药学学报 Acta Pharmaceutica Sinica 2010, 45 ( 10) : 1212 1223 海洋天然产物化学研究新进展 * 史清文, 李力更, 王于方, 霍长虹, 张嫚丽 (河北医科大学药学院天然药物化学教研室, 河北 石家庄 050017) 摘要: 近年来海洋天然产物越来越引起科学家们的关注。在浩瀚的海洋中存在着大量令人激动、活性独特、 结构新颖的次生代谢产物。海洋天然产物已成为发现重要药物先导物和新生物作用机制药物的主要源泉。本文 简要综述近5 年海洋天然产物化学研究进展。 关键词: 海洋天然产物化学; 海洋药物; 最新进展 中图分类号: R284 文献标识码:A 文章编号: 05 13-4870 (2010) 10-12 12-12 The recent research progress of chemistry of marine natural products * SHI Qing-wen , LI Li-geng, WANG Yu-fang, HUO Chang-hong, ZHANG Man-li (Depa rtment of Medicinal Natural Product Chemistry, College of Pharmaceutical Sciences, Hebei Medical University, Shij iazhuang 050017, China) Abstract: Ocean is a unique and excellent resource that provides a diverse array of intriguing natural products. Marine natural products have demonstrated significant and extremely potent biological activities and have captured the attention of natural products chemists in the past few decades. It is increasingly recognized that a wealth of fascinating natural products and novel chemical entities will play a dominant role in the discovery of useful leads for the development of pharmaceutical agents and provide useful probes to lead to breakthroughs in a variety of life-science fields. This article focused on the research progress of chemistry of marine natural products in recent five years. Key words: chemistry of marine natural products; marine medicine; research progress 生命起源于海洋, 海洋特殊生态环境中的生物 本文对近 5 年发现的结构特殊或生物活性显著的海 资源已成为拓展天然药用资源的新空间, 也是目前 洋天然产物如大环内酯类、聚醚类以及海洋萜类、甾 资源最丰富、保存最完整、最具新药开发潜力的新领