海洋真菌来源吲哚生物碱类化合物的结构和活性的研究.pdfVIP

热带海洋学报 JOURNAL OF TROPICAL OCEANOGRAPHY 2013 年 第 32 卷 第 1 期: 35−47 海洋生物资源 doi:10.3969/j.issn.1009-5470.2013.01.005 海洋真菌来源吲哚生物碱类化合物的结构和活性研究 李庆欣，史雪凤，黄智，田新朋，王发左 中国科学院南海海洋研究所, 中国科学院海洋生物资源可持续利用重点实验室, 中国科学院海洋微生物研究中心, 广东省海 洋药物重点实验室，广东 广州 510301 摘要: 近年来，海洋真菌因其能够产生大量结构新颖、活性显著的代谢产物而受到广泛关注。本文综述了 1991 —2010 年间从海洋真菌分离得到的 134 个新吲哚生物碱的结构和活性研究情况，其中包括fumitremorgin 类 19 个、 notoamide 类 22 个、细胞松弛素类 18 个、吲哚喹唑啉类 9 个、吲哚萜类 11 个、肽类及其他单吲哚类 21 个和双 吲哚类化合物 34 个。海洋真菌来源的吲哚生物碱不仅结构奇特，并且表现出多种重要的生物活性，具有潜在的 研究和应用价值。 关键词: 海洋真菌；吲哚生物碱；结构；活性 中图分类号: O629.3; P745 文献标识码: A 文章编号: 1009-5470(2013)01-0035-13 Indole alkaloids from marine-derived fungi: structures and activities LI Qing-xin ，SHI Xue-feng，HUANG Zhi ，TIAN Xin-peng ，WANG Fa-zuo Key Laboratory of Marine Bio-resources Sustainable Utilization , Research Network for Applied Microbiology (RNAM) Center for Marine Microbiology , Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences , Guangzhou 510301, China Abstract: In recent years, marine natural products of fungal origin have gained considerable recognition, as many of them possess novel structures and interesting biological and pharmacological properties. This review includes 134 indole alkaloids of marine-derived fungi with their structures and activities published during 1991−2010. Of the indole alkaloids, there were 19 fumitremorgins, 22 notoamides, 18 cytochalasans, 9 fumiquinazolines, 11 indole terpenes, 21 peptides and other single indole alkaloids, and 34 bisindole alkaloids. These indole alkaloids showed not only unique structures but also a variety of important biological activities and had potential values in application. Key words: marine fungi; indole alkaloids; structure; activity 近