Survivin在胃癌组织中的表达及其与幽门螺杆菌感染的关系.docVIP

Survivin在胃癌组织中的表达及其与幽门螺杆菌感染的关系 　　[摘要] 目的 探讨胃癌组织中Survivin的表达与临床病理因素及其与幽门螺杆菌（H.pylori）感染之间的关系。 方法 采用免疫组织化学方法检测60例胃癌组织中Survivin的表达情况；采用快速尿素酶法及Warthin-Starry银染色法检测60例胃癌组织中的H.pylori感染情况。分析Survivin表达与各临床病理因素及H.pylori感染的关系。所有患者随访至少5年或直到死亡。 结果 60例胃癌组织中Survivin表达阳性率为68.3%，肿瘤侵及固有肌层组（77.8%）和浆膜层组（60.0%）Survivin的表达高于肿瘤局限于黏膜及黏膜下层组（44.4%），差异有统计学意义（P中国论文网 /6/view-7216010.htm 　　[关键词] 胃肿瘤；Survivin；幽门螺杆菌；免疫组织化学 　　[中图分类号] R735.2 [文献标识码] A [文章编号] 1674-4721（2016）02（a）-0004-05 　　Relationship between Survivin expression and Helicobacter pylori infection in gastric cancer 　　JIAO Jian-xin1 WEN Feng-xia1 ZHANG Ling-ling2▲ JIAO Dong-sheng1 LI Lei1 JI Wan-sheng1 FENG Yu-guang1 ZHANG Xiao-qian1 　　1.Department of Gastroenterology，the Affiliated Hospital of Weifang Medical University，Shandong Province，Weifang 261031，China；2.Department of Oncology，Binzhou People′s Hospital，Shandong Province，Binzhou 256610，China 　　[Abstract] Objective To explore the relationship between Survivin expression and the clinicopathologic parameters of Helicobacter pylori （H.pylori） infection in gastric cancer. Methods In 60 patients with gastric cancer，expression of Survivin was detected by immunohistochemistry，H.pylori infection was determined by Warthin-Starry staining and rapid urease test.All the cases were followed up at least 5 years or until death.The relationship between Survivin expression and the clinicopathologic parameters，H.pylori infection was respectively analyzed. Results The positive rate of Survivin was 68.3% （41/60） in 60 patients with gastric cancer.The positive rate of Survivin in cases limited to muscularis and serosa was higher than that of Survivin in cases limited to mucosa and submucosa （77.8%，60.0%，44.4%，P 　　[Key words] Stomach Neoplasms；Survivin；Helicobacter pylori；Immunohistochemistry 　　胃癌是我国常见的恶性肿瘤之一，胃癌的发生发展与细胞的增殖凋亡密切相关。Survivin是凋亡抑制蛋白（inhibitor of apoptosis proteins，IAPs）成员之一，是迄今为止最强的凋亡抑制因子，Survivin不但能抑制肿瘤细胞的凋亡，而且还参与肿瘤新生血管的形成。幽门螺杆菌（Helicobacter pylori，H.pylori）感染是慢性胃炎、消化性溃疡的主要病因，亦与胃癌的