血脑屏障建模：神经保护的挑战和展望.docVIP

血脑屏障建模：神经保护的挑战与展望 血脑屏障形成了血液和大脑之间的高度选择性接口。过去几年的广泛研究工作已经完全改变了我们对血脑屏障的认识与观点，即从一种静态的、不可渗透的阻碍到动态的、高度调节性和具体的细胞系统。血脑屏障超微结构包括特别脑微血管内皮细胞，其特征为低吞饮活性，无开口以及具体和极化跨细胞运输系统表达。脑微血管内皮细胞由蛋白质复合体组成，具有紧密相互连接特性，可导致高电阻和低细胞旁渗透性。附加周细胞和星形细胞端脚进程也积极参与到血脑屏障特性的诱导、维持和调整过程中。与平滑肌细胞一起，神经元和循环血液细胞共同形成了神经血管单元的复杂系统。神经血管单元会控制血管和中枢神经系统中的流体、分子和细胞，并整合生理和病理信号，如代谢需要、流变扰动和炎性刺激之间的细胞过渡。 德国明斯特大学Tobias Ruck在发表在2015年6月第6期《中国神经再生研究（英文版）》杂志上的观点文章中主要阐述了血脑屏障功能障碍或紊乱是中枢神经系统中主要或继发损伤（引起全身性疾病）标志，如神经血管感染、炎性或退行性疾病的发病机理。因此，血脑屏障的研究会给多个领域带来更多启发和发展，包括神经科学/神经内科、（病理）生理学、药理学、内科和更多学科。 Article: Blood-brain barrier modeling: Challenges and perspectives by Tobias Ruck, Stefan Bittner, Sven G. Meuth (Department of Neurology, University of Münster, Münster, Germany) Ruck T, Bittner S, Meuth SG (2015) Blood-brain barrier modeling: Challenges and perspectives. Neural Regen Res 10(6):889-891. 欲获更多资讯：请与《》联络；联络电话：，或用电子邮件联络：eic@。/ Blood-brain-barrier modelling: Challenges and Perspectives in Neuroprotection The blood-brain-barrier (BBB) forms a highly selective interface between blood and brain. Extensive research efforts have completely changed our view of the BBB in the last years, from a static, impermeable barrier to a dynamic, highly regulated and specific cellular system. The BBB ultrastructurally consists of specialized brain microvascular endothelial cells (BMEC) characterized by low pinocytic activity, absent fenestrations and expression of specific and polarized transcellular transport systems. BMECs are interconnected by protein complexes consisting of tight and adherens junctions leading to high electrical resistance and low paracellular permeability. Attached pericytes and astrocytic end feet processes are critically involved in induction, sustaining and regulation of the BBB properties. Together with smooth-muscle cells, neurons and circulating blood-cells they form the complex system of the neurovascular unit (NVU). The NVU controls the transition of fluids, molecules and cells between blood vessels and the CNS integrating physio