益气健脾化积方对胃癌化疗增效的理论机制探讨.doc

益气健脾化积方对胃癌化疗增效的理论机制探讨 　　[摘要] 本文就益气健脾化积方对胃癌化疗的增效作用从方剂组方结构理论及意义、化疗的证机变化与“方证相应”的证治立法基础以及方剂所含药物抗癌药理作用等三个方面进行了理论分析，认为该方对胃癌化疗发挥的增效作用是建立在中医的理、法、方、药的理论基础之上，且与辨证用药的传统中药功效理论及所含药物的抗癌药理作用相关。 中国论文网 /6/view-7218249.htm 　　[关键词] 益气健脾化积方；胃癌；化疗增效；理论机制 　　[中图分类号] R735.7 [文献标识码] A [文章编号] 1673-7210（2016）01（a）-0095-03 　　Discussion on the theoretical mechanism of the chemotherapeutic synergy of Replenishing Qi to Invigorate the Spleen and Relieve Stasis Decoction for gastric cancer 　　LI Kun1 LIN An’an1 ZHU Fangshi1，2 　　1.The First Clinical Medicine College， Nanjing University of Chinese Medicine， Jiangsu Province， Nanjing 210023， China； 2.Clinical Laboratory of Integrated Chinese and Western Medicine， Integrated Traditional Chinese and Western Medicine Hospital Affiliated to Nanjing University of Chinese Medicine， Jiangsu Province， Nanjing 210028， China 　　[Abstract] This article discusses and analyzes about the theoretical mechanism of the chemotherapeutic synergy of Replenishing Qi to Invigorate the Spleen and Relieve Stasis Decoction to the patients with gastric cancer， which is from the theory and significance of prescription structure， the legislative basis for treatment card machine change chemotherapy and “corresponding of prescription and syndrome”， as well as the pharmacological effects of drugs in the prescription， it is thought that the chemotherapeutic synergy on gastric cancer is based on the TCM theory， methods， prescriptions and medicine， and related to the traditional Chinese medicine efficacy theory for syndrome differentiation and anticancer pharmacological effects of the drug. 　　[Key words] Replenishing Qi to Invigorate the Spleen and Relieve Stasis Decoction； Gastric cancer； Chemotherapeutic synergy； Theoretical mechanism 　　化疗是治疗胃癌的有效手段之一，但化疗药物引起的恶心、呕吐等胃肠道反应以及骨髓抑制、机体免疫系统的破坏等细胞毒作用严重影响了化疗的疗程和效果。因此，人们期望从中医角度寻找能减轻化疗毒副作用、并能协同提高化疗效果的药物。益气健脾化积方为国家师承名医指导老师、南京中医药大学博士生导师刘沈林教授治疗胃癌的经验效方，多年来应用于临床疗效肯定，与化疗药物配合使用具有增效减毒作用，本文仅就益气健脾化积方对胃癌化疗增效的理论机制试作探讨。 　　1 益气健脾化积方组方结构及意义诠解 　　益气健脾