血清CTX―Ⅱ、COMP在关节镜清理术治疗膝骨关节炎前后变化及临床意义.docVIP

血清CTX―Ⅱ、COMP在关节镜清理术治疗膝骨关节炎前后变化及临床意义 　　【摘要】 目的：探讨关节镜清理术治疗膝骨关节炎（knee osteoarthritis，KOA）对血清CTX-Ⅱ、COMP的影响，对比术前术后血清CTX-Ⅱ、COMP含量以了解患者术后膝关节软骨修复情况。方法：选取2013年1月-2015年6月本院行关节镜清理术的膝骨关节炎患者60例，根据ICRS分级方法按病情分为Ⅰ级组18例、Ⅱ级组23例、Ⅲ级组11例、Ⅳ级组8例。用ELISA法测定患者术前及术后1周、1个月、3个月血清CTX-Ⅱ和COMP含量，采用WOMAC评分评价患者术前术后膝关节功能。结果：不同分级患者关节镜清理术后1周、1个月、3个月WOMAC评分均较术前显著降低，差异均有统计学意义（P0.05）。各组患者血清CTX-Ⅱ、COMP含量于术后1个月、3个月较术前均显著降低，差异均有统计学意义（P中国论文网 /6/view-7251484.htm 　　【关键词】 Ⅱ型胶原羧基端端肽； 骨寡聚基质蛋白； 软骨修复； 膝骨关节炎； 关节镜清理术 　　The Variation and Clinical Significance of Serum CTX-Ⅱ and COMP in Knee Osteoarthritis Patients before and after Treatment with Arthroscopic Debridement/ZOU Xin-ming，ZHAN Wei-bing，FAN Nai-ren.//Medical Innovation of China，2016，13（09）：013-017 　　【Abstract】 Objective：To study the influence on serum CTX-Ⅱ and COMP of arthroscopic debridement in the treatment of knee osteoarthritis patients，and to evaluate the joint cartilage repairing progress via comparing the level of serum CTX-Ⅱ and COMP before and after operation.Method：Sixty patients with knee osteoarthritis who underwent arthroscopic debridement in our hospital from January 2013 to June 2015 were selected，they were divided into the four groups according to the ICRS grade，which includes 18 patients in the grade Ⅰ group， 　　23 patients in the grade Ⅱ group，11 patents in the grade Ⅲ group and 8 patients in the grade Ⅳ group.The serum CTX-Ⅱ and COMP of all patients were detected by ELISA before arthroscopic debridement operation and at 　　1 week，1 month and 3 months after the operation.Patients knee functions were evaluated by measurements of WOMAC score at the same time.Result：The WOMAC scores of patients in different groups all decreased at 　　1 week，1 month and 3 months after the operation than before operation，the differences were statistically significant（P0.05）.Compared with before operation，the serum CTX-Ⅱ and COMP of all four groups were significantly decreased at 1 month and 3 months after the operation，the differences were statistically signific