哌唑嗪：脊髓损伤后自主神经反射异常新式管理工具？.docVIP

哌唑嗪：脊髓损伤后自主神经反射异常的新式管理工具？ 脊髓损伤是一种破坏性病理条件，不仅会导致运动功能丧失，严重的自发性功能障碍也是一种损伤。自主神经反射异常是颈或高胸脊髓损伤患者瞬时高血压引起的危及生命的并发症，发生率多达30倍/天（平均11倍/天）。主神经反射异常最常见的触发机制是由刺激完整的肠和/或膀胱功能，或性功能唤起。 最近，加拿大英属哥伦比亚大学Aaron A. Phillips博士研究小组发表的一项临床试验重点解释了哌唑嗪可能是治疗自主神经反射异常的又一个可行选择。他们首次证明了1毫克哌唑嗪口服给药对脊髓损伤中减轻源性诱发自主神经反射异常严重性上非常有效。重要的是，哌唑嗪并不会使脊髓损伤患者的低静息血压加剧。相关内容发表在2015年4月第4期《中国神经再生研究（英文版）》杂志上。 Article: Prazosin: a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury? by Mei M.Z. Zheng1, 3, Aaron A. Phillips1, 2, 3, Stacy L. Elliott3, 4, 5, 6, 7, Andrei V. Krassioukov3, 7, 8 (1 Experimental Medicine Program, Faculty of Medicine, University of British Columbia, Vancouver V5Z 1M9, Canada; 2 Centre for Heart, Lung, and Vascular Health, Faculty of Health and Social Development, University of British Columbia, Kelowna V1V 1V7, Canada; 3 International Collaboration on Repair Discoveries (ICORD), University of British Columbia, Vancouver V5Z 1M9, Canada; 4 Department of Psychiatry, University of British Columbia, Vancouver V6T 2A1, Canada; 5 Department of and Urologic Sciences, University of British Columbia, Vancouver V5Z 1M9, Canada; 6 Vancouver Sperm Retrieval Clinic, Vancouver Coastal Health Authority, Vancouver V5Z 1M9, Canada; 7 G.F. Strong Rehabilitation Center, Sexual Health Rehabilitation Service, Vancouver V5Z 2G9, Canada; 8 Division of Physical Medicine and Rehabilitation, Department of Medicine, University of British Columbia, Vancouver V5Z 2G9, Canada) Zheng MMZ, Phillips AA, Elliott SL, Krassioukov AV (2015) Prazosin: a potential new management tool for iatrogenic autonomic dysreflexia in individuals with spinal cord injury? Neural Regen Res 10(4):557-558. 欲获更多资讯： Prazosin: a potential new management tool for autonomic dysreflexia in individuals with spinal cord injury? Spinal cord injury (SCI) is a devastating condition that not only results in a loss of motor functions but also severe autonomic dysfunctions. Autonomic dysreflexia (AD) is a life threa