APC及抗原提呈翁精要.pptVIP

* * 在某些情况下 内源性抗原也能通过MHC-II类分子提呈 外源性抗原也能通过MHC-I类分子提呈 * Y Y Pinocytosis Phagocytosis Membrane Ig receptor mediated uptake Y Uptake of exogenous antigens Complement receptor mediated phagocytosis Y Fc receptor mediated phagocytosis opsonization Proteases produce ~24 amino acid long peptides from antigens Drugs that raise the pH of endosomes inhibit antigen processing Endosomes Exogenous pathway Increase in acidity Cell surface To lysosomes Uptake Protein antigens In endosome Cathepsin B, D and L proteases are activated by the decrease in pH Pathway for Peptide+MHC-II Formation, from Endocytosis P