EvaluationofinvitroInhibitoryEffectonCYP450EnzymesActivityinFreshlyIsolatedHepatocytes.docVIP

Evaluation of in vitro Inhibitory Effect on CYP450 Enzymes Activity in Freshly Isolated Rat Primary Hepatocytes Sponsor Study Monitor Study Director Testing Facility Study Identification Medicilon/MPT Study Number Medicilon/MPT Protocol Number Protocol Issue Date Sponsor Approval Date Page Number OBJECTIVE This assay is designed to evaluate the ability of test articles to inhibit CYP450 1A2, CYP450 2C9, CYP450 2C19, CYP450 2D6, CYP450 3A4 following incubation with freshly isolated rat primary hepatocytes. The results will be served as bedrocks for further investigation o