新抗体制药技术方案.pptVIP

Cancer cell ? * * * * * * IMMUNOGLOBULINANTIBODY MEDICINE The difference between immunoglobulin and antibody Immunoglobulin is a kind of globulin with antibody activity or semblable structure. Antibody is a kind of globulin which can specifically bind with corresponding antigen. The Classification ? secreted immunoglobulin， sIg (分泌型免疫球蛋白) ?membrane immunoglobulin，mIg (膜型免疫球蛋白) The basic structure Ig consists of four peptide chains Two light chains，L链 : Including 214 amino acids，(type ? and ? ). Two heavy chains，H链 : Including 450 ~ 550 amino acids，type ?（IgA）、 ?（IgG）、?（IgD）、?（IgM）、?（IgE）. Five types Main features and functions of 5 classes of immunoglobulins Ig G Ig M Ig A IgG 1. Most of it exists in our serum (75-80%) 2.It’s the main antibody to fight injection. 3. It’s the only Ig which could pass through maza. So the new baby could get immunity through his/her mother. IgM 1.It has the largest molecular weight . 2.It’s the Ig formed earliest in our body. 3.In the early stage, it’s the first one to participate in the immune response. So it plays an important role in the early immune defense. IgA 1.It has two subtypes, serotype and secretive type 2.It exists on the surface of mucosa or chorion and all kinds of external secretion. So it’s an important antibody for mucosa. 细胞膜的外表面 内吞作用 细胞膜上表面二聚物igA的释放 Functions of immunoglobulin Dissolve cells Prevent pathogene Co-conditioning function Go through maza Bind with FC receptor The conditioning function The function of Ig Combine with antigen and neutralize the toxin Agglutinate of bacteria Antibody attacks virus America FDA has allowed these antibody medicines to the market Orthoclone ReoPro Rituxan Zenapax Simulect Synagis Remicade Herceptin Mylotarg Campath-1H Zevalin 移植排斥 心绞痛 B细胞非霍奇金淋巴瘤 移植排斥 移植排斥 婴儿呼吸道合胞病毒 类风湿关节炎 乳腺癌 急性复发性髓性白血病 难治性慢性淋巴细胞白血病 难治性B细胞非霍奇金淋巴瘤 1986 1994 1997 1997 1998 1998 1998 1998 2000 2001 2002