吡唑并[1,5-a]吡啶类化合物的发光性质研究创新.docVIP

摘要 含氮杂环化合物在自然界中分布很广，功用也很多。例如，中草药中的有效成分生物碱大多都是含氮化合物；在动植物体内起着重要生理作用的血红素、叶绿素、核酸的碱基都是含氮化合物。因此，合成研究含氮杂环化合物具有非常重要的意义。五元并六元的氮桥头杂环化合物包括中氮茚类、吡啶并苯并咪唑类、吡唑并吡啶类、咪唑并吡啶类等，这些化合物具有广泛的生物活性，例如抗肿瘤活性、多巴胺受体拮抗剂、38激酶抑制剂和抗疱疹病毒等活性。 近年来，含氮杂环化合物在生物探针、荧光染料和光电材料领域的应用也越来越多。在生物研究领域，含氮杂环化合物作为细胞染色剂或生物探针被广泛深入的研究；在光电材料领域，结构独特的含氮芳香体系作为有机半导体材料在有机电致发光和有机场效应晶体管等器件中具有重要应用。目前对于氮桥头类杂环化合物的研究主要集中在合成方法和生物活性方面，而这类化合物的光学性质被研究报道的很少。 利用串联反应合成了一系列吡唑并吡啶类化合物。初步的光学性质测试表明，这类化合物显示出独特的光学特性。因此详细研究了吡唑并[1，5-a] 吡啶系列化合物的光学性质。 ：吡唑并[1，5-a]吡啶；发光性质；荧光；紫外 Abstract Nitrogen heterocyclic compounds is widely distributed in nature, the function is very much also. For example, The effective components alkaloids in Chinese herbal medicine are mostly nitrogen compounds; The hemoglobin,chlorophyll, nucleic acid bases of animals and plants play an important physiological function are nitrogen compounds; Therefore, the synthesis of nitrogen heterocyclic compounds have very important significance. Of these heterocycles, compounds containing indolizines, pyrazolo[1,5-a]pyridines, pyrido[1,2-a]benzimidazoles, imidazo[1,2-a]pyridines and imidazo[1,5-a]pyridines have been reported to possess a wide variety of biological and pharmacological properties. Furthermore, some of these compounds have a wide range of biological activities, such as antitumor activity, dopamine receptor antagonist, P38 lightning kinase inhibitors and against herpes virus activity. In recent years, nitrogen-containing heterocyclic compounds in biological probes, fluorescent dyes field and photovoltaic materials is also increasing. In biological research, a nitrogen-containing heterocyclic compounds are extensively studied as a cell stain or biological probes; In the field of photoelectric material, the unique structure of the nitrogen-containing aromatic system as an organic semiconductor material in organic electroluminescent and organic field effect transistors and other devices that have important applications. At present，the bridgehead nitrogen heterocyclic compounds r