颈动脉粥样硬化斑块稳定性蛋白质组学初步研究.pdf

ABSTRACT Background Atheroscleroticisoneofthemost plaque importantmorbigenousfactors．However, themechanisms formationand arenot underlyingplaque progressioncompletely believethat of rolein known．Recent the an study instability important plaqueplays theoccurrenceofnervous ofthe factorsofcarotid systems．Explorationaffecting toa ofatherosclerotic arteryplaquestability,contributedeeperunderstanding mechanisms．Seriesof are for factorsfound of pathophysiological affectinginstability the nonecan thecausesof the plaque，but perfectlyexplain plaqueinstability．In new factors tohuman study，weexpect present affectingbyapplyingproteomics carotid extracts。 arteryplaque objectives thedifferencesbetween theinstablein Compare thestableareaand areathesame vulnerable plaquebyproteomics． Methods Thecriteriafor werethe ofathinfibrousorfissured plaqueinstability presence cap the ornecrotic the of coveringfoamy core，and cap presenceovert，hemorrhagic， ulceratedorthrombotic divided3 from intostable plaques．Weplaqueendarterectomy instableareas and wereextractedfrom minced respectively．Proteins finely specimens，