抑制Dicer基因对乳腺癌细胞MCF-7周期与药物敏感性的影响.pdf

中国医学科学院基础医学研究所 北京协和医学院基础学院 硕士研究生毕业(学位)论文 Abstract 22nucleotide RNA．Recent MicroRNAs(miRNAs)areapproximately non-coding researcheshaveshownthataberrant ofmiRNAsinvarioushumancancers expression rolefor in cancerisoneofthemostcommon a miRNAs suggests tumorigenesis．Breast tumorsin incidencerateis tothe malignant women,whose nearlyup first，severely threatenswomen’Shealthandlife．Itis thataberrant ofmiRNAs reported expression play in and isanessential roles chemosensitivity．Dicer importantcarcinogenesis，progression memberoftheRNaseIII which executesthe of of family specifically cleavageprecursors 70 thematurationofmiRNAsinthe nucleotides(pre-miRNAs)and approximately miRNAsthen the totheir ability cytoplasmicprocessing，maturatedpossesinhibiting translational ofDicerin cancerand genesby prostate targeting repression．Overexpression adenocarcinomahasbeen the modulatorof lung reported．Asup—stream miRNAs，Dicer analmost increaseofmiRNAs in cancer，and up-regulationmayexplain global expression themodulationofDicerwill induce of behavioroftumor biological undoubtedlychanges