N-linkedglycosylation-1.ppt

Glycobiology Chart 2. N-linked Glycosylation Major Glycan Classes in Animal Cells Extracellular N-glycans in vertebrates exist as high-mannose ,hybrid, or complex subtypes Major Classes of N-Glycans 2.2 Assembly of N-linked glycans occurs in three major stages Formation of a lipid-linked precursor oligosaccharide En bloc transfer of the oligosaccharide to the polypeptide Processing of the oligosaccharide, processing steps include removal of some of the original sugar residues (trimming) following by addition of new sugars at the non-reducing termini of the glycans. 2.3 The precursor olig