系统生物学绪论.ppt

Taxonomic distributions of pathways Pdepleted-value = Phylophenetic properties of single pathways The pathway set based tree 二、非编码区功能研究 该工作发表于Nucleic Acids Research 2005 年第一期，被2005年1月21日出版的”Science”做了专门介绍（证明材料）。韩国已要求成为我们的镜象。 上网仅最初的两个多月点击我们数据库的已超过12万次（平均每天约2000次）来自约60，000个不同的IP地址，几乎包括了世界上最重要的研究单位，象：哈佛大学、斯坦福大学、剑桥大学等。 谢谢各位！ * * Conceptually, each “ome” map can be conceived as a two-dimensional matrix. The X axis represents the genome, the complete set of ORFs (ORFeome; see Walhout et al., 2000b), or the proteome. The Y axis repre-sents a set of conditions, genetic back-grounds or phenotypes, or even the proteome itself (see text for details). Overlapping maps in the Z axis constitute the biological atlas. * Hypothesis-driven research concentrates on one protein and uses many different tools for its characterization. We refer to the vertical arrow as the “vertical approach.” Large-scale functional genomics experiments apply the same tool to many if not all genes or proteins. We refer to the horizontal arrow as the “horizontal approach.” * New, better algorithms Integration. Collaboration Complex queries, e.g. “what are the known protein kinases in the yeast genome that are involved in cell division and how many of these have homologues in plants?” * c, A portion of the molecular interaction map for the regulatory network that controls the mammalian cell cycle 6 . Colours indicate different types of interactions: black, binding interactions and stoichiometric conversions; red, covalent modifications and gene expression; green, enzyme actions; blue, stimulations and inhibitions. * Strategies used to link functionally related yeast proteins, showing the number of links provided by each method. 4,130 very high confidence links were constructed from experimental data, between proteins of related metabolic function, and from links generated by at least two of the prediction methods. 19,521 high confidence links were constructed from the phylogenetic profile method whe