中科院细胞与分子免疫学课程Chapter材料.pptVIP

* D J 7 12 9 V4 7 23 9 V4 and DJ in opposite transcriptional orientations D J 7 12 9 V4 7 23 9 1. D J 7 12 9 V4 7 23 9 3. D J 7 12 9 V4 7 23 9 2. D J 7 12 9 V4 7 23 9 4. Non-deletional recombination * D J 7 12 9 V4 7 23 9 1. D J V4 7 12 9 7 23 9 3. V to DJ ligation - coding joint formation D J 7 12 9 V4 7 23 9 2. Heptamer ligation - signal joint formation D J V4 7 12 9 7 23 9 Fully recombined VDJ regions in same transcriptional orientation No DNA is deleted 4. * 7 D 12 9 J 6.Generation of Diversity of the B and T Cell Repertoires Junctional diversity: P nucleotide additions 7 V 23 9 D 7 12 9