白藜芦醇对小鼠白色脂肪棕色化的影响及机制分析-南京体育学报学报.docVIP

白藜芦醇诱导白色脂肪组织棕色化的研究进展 于鹏1张慧2 (河南大学体育学院，河南 开封 475001) 收稿日期: 2015-07-14 于鹏1(1989年-), 男, 河南开封，在读硕士研究生，研究方向：运动生理生化理论与实践。河南大学体育学院，河南省开封市顺河回族区 475001； 张慧2（1978年-）,男,河南周口，副教授，硕士研究生导师，研究方向：运动生理生化理论与实践。河南大学体育学院，南省开封市顺河回族区 475001。 摘 要：哺乳动物体内的棕色脂肪组织（brown adipose tissue，BAT）主要储存能量的相比,因线粒体解偶联蛋白1(uncoupling protein-1,UCP1)而拥有非颤栗产热的能力（Beige AdipocytesSilent information regulator 1, SIRT1），SIRT1通过配体依赖方式去乙酰化过氧化物酶体增殖体激活受体(（Peroxisome proliferator activated receptor (, PPAR(），抑制过氧化物酶体增殖物激活受体(辅助激活因子-1α（peroxisome proliferator activated receptor ( coactivator-1α,PGC-1α)的去乙酰化作用及其与PPARγ的交互作用等减少脂肪生成和脂质蓄积，促进脂肪分解速率，诱导线粒体生成，提高线粒体生物氧化功能，线粒体解偶联蛋白1 (uncoupling protein 1,UCP-1)表达增加等进而诱导白色脂肪棕色化的可能机制，探讨白藜芦醇诱导白色脂肪棕色化的信号通路，为今后的研究作出展望。 关键字：白藜芦醇； SIRT1；PPAR(；PGC-1α；白色脂肪棕色化 The Progression of Resveratrol induced browning of white adipocytes YU Peng1,ZHANG Hui2 Abstract：ared?with?the?main?store?energy?white?adipose?tissue,WAT?the?brown?adipose?tissue?of?mammals?who?has?rich?mitochondria?UCP1?ability?to?non-shivering?thermogenesis?.Beige?Adipocytes?has?path?of?adipocyte?which?can?find?the?difference?between white and brown adipocytes，but make?the?same?physiological?function?with?brown?fat?in?the?body.?It?has?not?only??a?very?high metabolic?rate?,but?also?can?play?an?important?role?in?activating?the?beige?fat?brown?fat?specificity?expressing?genes?in?white?fat?brown. Resveratrol activated adipose tissue SIRT1（Silent information regulator 1）, SIRT1 deacetylated PPAR(（Peroxisome proliferator activated receptor (）by ligand dependention, restrain deacetylated of PGC-1α（peroxisome proliferator activated receptor ( coactivator-1α) and its interaction with PPAR(, Decrease adipose generation and accumulation of lipid, promoted adipose decompose rate, abduction of mitochondria, improve mitochondrial function of biological oxidation, increase of expressionin mitochondrial UCP1, the possible mechanism of induction of white fat brown, The paper then investigates the signal pathway of the resveratrol induced browning