10%20刘芬%20麦星宇disorders%20associated%20with%20G.ppt

Disorders Associated with GPCRs Various types of diseases caused by defective GPCRs * By 刘芬 1080800103 麦星宇 1080800105 Fig.1 Putative membrane tography of G protein coupled receptors represents the largest family of genes encoded by the human genome. Their importance in human biology is reflected by the fact that over one-third of all prescription drugs act as ligands that bind to this huge superfamily of receptor. A number of inherited disorders have been traced to defects in both GPCRs and hetreotrimeric G protein. A rod photoreceptor cell Retinitis Pigment (RP) An inherited disease. Chara