15 血必净注射液对危重患者凝血功能障碍的研究.docVIP

血必净注射液对危重患者凝血功能障碍的研究 杨立山 马晓 李文峰 丁勇 （宁夏医科大学总医院急诊科，银川 750004） 作者简介：杨立山（1965-）男，主任医师，硕士，从事急诊医学专业。 「摘要」 目的：研究血必净注射液对急诊重症监护室危重患者凝血功能障碍的临床影响。方法：将100例收入急诊重症监护室凝血功能障碍的危重患者分为血必净组和对照组各50例。两组患者均给予常规治疗，血必净组患者加用血必净注射液治疗。对比两组患者住院天数、年龄等一般指标，同时监测两组患者入院时、治疗第5天及治疗第10天凝血酶原时间(PT)、活化部分凝血酶原时间(APTT)、凝血酶时间(TT)、纤维蛋白原定量(FIB)、D-二聚体定量(DD)的动态变化。结果：两组患者年龄比较无明显差异(p﹥0.05)，住院天数血必净组较对照组缩短(p﹤0.05)。各项凝血指标上：入院时两组比较差异无统计学意义(p﹥0.05)。治疗第5天血必净组PT、APTT、FIB、DD等指标明显恢复，而对照组却恢复较差，比较差异有统计学意义(p﹤0.05)；而TT两组比较差异无统计学意义(p﹥0.05)。治疗第10天时除DD两组比较差异无统计学意义(p﹥0.05)外，其余凝血指标均比较差异有统计学意义(p﹤0.05)。结论：血必净注射液对凝血功能障碍危重患者的凝血功能有很好的保护作用，有很好的临床使用价值。 「关键词」 血必净注射液；凝血功能障碍。 The research of Xuebijing injection in coagulation dysfunction of severe patients 「Abstract」Objective:；To research the clinical infectiom of Xuebijing injection in coagulation dysfunction of Emergency Intensive Care Unit severe patients；Methods:Choose 100 severe patients from Emergency Intensive Care Unit with coagulation dysfunction.divided two groups,50 patients with Xuebijing injection, 50 patients without Xuebijing injection.all cases were treated with routine combined therapy, the treatment group were treated with Xuebijing injection.To record the days in hospital and the age et,Before the treatment and 5,10 day after the treatment PT,APTT,TT,FIB,DD in two groups were recorded and analyzed；Results: There was no obvious difference in two groups about age(p﹥0.05),the treatment group was shorter than the comtrol group about days in hospital(p﹤0.05). when in hospital,the all indicators were no difference in two groups(p﹥0.05).5 day after the treatment , PT、APTT、FIB、DD in treatment group have obvious recover，but another group was not so,there have difference(p﹤0.05). meanwhile there was no difference in two groups about TT(p﹥0.05). 10 day after the treatment , there was no difference in two groups about DD(p﹥0.05), there have difference in two groups about others indicators(p﹤0.05)；Conclusion: Xuebijing injection has an protection effect on coagulation function,