抑郁症及其药物治疗李乐华课程.ppt

* With fluvoxamine, activity at sigma receptors might explain its notable efficacy in delusional depression. To date there does not seem to be a conclusive explanation, in terms of it’s pharmacologic profile, for the higher levels of nausea and sedation seen in clinical practice. What positive or negative effects could modulation of sigma neurotransmission add to an SSRI? The “sigma enigma” - it is possible that this could give greater antipsychotic actions to a drug, greater anxiolytic actions to a drug, but it could also increase GI motility. The agents for which sigma properties may be rele