细胞工程制药详细分析.ppt

+ - Sialidase ? ? ? ? ? ? 2001.Konenbreg, The generation and presentation of glycolipid for CD1d ?-GalCer Gal ?1,6GalCer + CD1d-coated plate + + APC + + ?-Gal A-/- APC + Gal ?1,2GalCer +NKT hybridomas - ?-Gal A (lysosomal glycosidase~ Gal ?1,2/ ?1,4) 2004.Bendelac, Lipid transfer protein (LTP) Hypothesis: Lysosome is a most important compartment for efficient CD1d antigen presentation that provides glycosidases and lipid transfer proteins NKT cell antigen presentation pathway is that glycolipids are endocytosized and processed with glycosidases in lysosome. The presentation of the di