三氧化二砷吸入治疗中心型肺癌临床研究.docVIP

【摘要】 　　目的 探讨经支气管雾化吸入三氧化二砷(As2O3)治疗中心型肺癌的疗效及副作用。方法 中心型肺癌患者41例，治疗前常规行肺CT、血常规、心肌酶、肝、肾功能检查。将病人按本人及家属意愿分为两组，两组年龄、性别、身体状况、伴有的并存疾病相当，具有可比性。试验组以高流量氧喷射雾化吸入方法吸入As2O3，对照组以同样方法吸入顺铂，疗程28 d。疗程结束后1 w，重复治疗前各项检查。按WHO标准评定疗效和毒性反应。结果 As2O3对三种病理类型的肺癌都有作用，总有效率CR+PR试验组6190%明显高于对照组5500%(P＜005)，其中对腺癌的作用更突出，试验组3例均达到了部分缓解，而顺铂对照组3例中只有2例保持无变化，1例进展。不良反应比较：试验组有2人产生咽喉部刺激，而对照组有8人产生，且程度超过试验组。试验组中两例咽喉部有轻度刺激的患者行支气管镜检查，未发现支气管黏膜有明显的充血和水肿。两组患者均未发现治疗后肝功、心肌酶改变及WBC下降。结论 经支气管雾化吸入As2O3治疗中心型肺癌的疗效肯定，毒副作用小，是治疗老年人中、晚期中心型肺癌的较理想方法。 【关键词】 中心型肺癌　As2O3　雾化吸入 　　Inhibitory effect of methyl mercury on proliferation of rat Lewis lung cancer cells 　　DING Hui, ZUO MengHua, LIU ChaoYing, et al 　　Department of Respiratory, the First Hospital of Jilin University, Changchun 130021, Jilin, China 　　【Abstract】 Objective To investigate the inhibition of methyl mercury on the proliferation of rats Lewis lung cancer cells and to compare that of As2O3 and cisplatin. Methods MTT chromatometry was used. Control group was only added with culture fluid. Cultured Lewis cells were stimulated with different doses (40, 20, 10, 5, 2.5 μmol/L) of methyl mercury, As2O3 and cisplatin. The proliferations of Lewis lung cancer cells were determined by detecting optical density value at 570 nm wave length with DG3022A ELISA. And the growth density and morphological changes of Lewis lung cancer cells were observed by reversed microscope. Results Methyl mercury could inhibit the proliferation of rats Lewis lung cancer cells, having time and dosedependence. The difference of the same concentration but at the different time and the difference of the same time but at the different concentration were significant (P＜0.001). The inhibition of methyl mercury on the proliferation of Lewis cells of rats in lung cancer was stronger than that in of As2O3 and cisplatin, exhibiting lower action concentrations and quicker action time.Conclusions Methyl mercury could inhibit the proliferation of rats Lewis lung cancer cells with time and dosedependenc