Chapter10HumanGeneMappingandDiseaseGeneIdentification精品资料.ppt

Chapter 10 Human Gene Mapping and Disease Gene Identification;Two fundamental approaches to disease gene identification (2种鉴定疾病基因的基本方法);THE GENETIC LANDSCAPE OF THE HUMAN GENOME（人类基因组的遗传学全貌）;Independent Assortment and Homologous Recombination in Meiosis（减数分裂中的自由组合和同源重组）;Alleles at Loci on Different Chromosomes Assort Independently（各染色体基因座上的等位基因进行自由组合）;Alleles at Loci on the Same Chromosome Assort Independently if at Least One Crossover Occurs Between Them in Every Meiosis（同一条染色体上基因座的等位基因每次减数分裂至少发生一次交换的自由组合情况）;Recombination Frequency and Map Distance（重组频率和图距）;Effect of Heterozygosity and Phase on Detecting Recombination Events（杂合子和相位对重组事件的影响）;Linkage and Recombination Frequency（连锁和重组频率）;Genetic Maps and Physical Maps（遗传图和物理图）;;Linkage Equilibrium and Disequilibrium（连锁平衡和不平衡）;;;The Haplotype Map (HapMap) （单体型图）;;MAPPING HUMAN GENES BY LINKAGE ANALYSIS（连锁分析定位人类基因）;;MAPPING OF COMPLEX TRAITS（复杂性状的基因定位）;Model-Free Linkage Analysis of Complex Disease Traits（复杂疾病性状的非模型连锁分析）;Model-Free Linkage Analysis of Qualitative (Disease) Traits 质量（疾病）性状的不依赖模型的连锁分析;False-Positive Errors;;Model-Free Linkage Analysis of Quantitative Traits（数量性状的不依赖模型的连锁分析）;Disease Association（疾病关联分析）;Strengths and Weaknesses of Association Studies（关联分析的利弊）;;Genome-Wide Association and the Haplotype Map（全基因组关联分析和单体型图）;Tag SNPs（标签SNPs）;;Linkage（连锁分析）;;Association（关联研究）;;FROM GENE MAPPING TO GENE IDENTIFICATION（从基因定位到基因鉴定）;Positional Cloning of an Autosomal Recessive Disorder by Model-Based Linkage Mapping: Cystic Fibrosis（运用模型连锁分析法定位克隆常染色体隐性遗传病：囊性纤维化）;Positional Cloning of a Complex Disease by Genome-Wide Association: Age-Related Macular Degeneration （通过全基因组关联分析定位克隆复杂疾病：老年性黄斑变性）;