碘-125放射粒子组织间植入治疗恶性肿瘤资料.ppt

Primary Clinical Study of CT-guided Iodine-125 Seed Implantation Therapy in Patients with Advanced Pancreatic Cancer 上海交通大学医学院附属瑞金医院卢湾分院 王忠敏;Brachytherapy;生物学优势（外放疗相比）;Implant radioactive seeds into tumors;; Human pancreatic cancer Sw1990 cell BABL/c was inoculated into the dorsal side of right lower extremity inguinal region of nude mice Passaged for 3 tims subcutaneously, initiate the experiments after tumor formation was stablized ; Subcutaneous pancreatic cancer xenograft in nude mice;Change of xenograft volume in nude mice ;Comparison of tumor inhibition rate ;Obvious liquefaction necrosis can be seen in the centeral area of Experimental group tumor, there are sparse cells aroud the necrosis area (×100) ;Experimental group positive TK1 staining cells are exiguous（×200） ; 碘-125放射粒子组织间植入治疗属放射治疗， 对周围??常器官组织无明显放射损伤 裸鼠移植瘤组织植入碘-125粒子后，实验组心、 肺、肝、肾、脾脏外观大致正常，病理检查未 见明显放射性炎症表现 ;ZM. Wang MD, Shanghai Ruijin Hospital;Traditional therapy vs. External irradiation therapy vs. percutaneous seed implantation;; ;ZM. Wang MD, Shanghai Ruijin Hospital;Methods and materials ;Methods and materials ;适应症;禁忌证 ;Iodine-125 Therapy in Advanced Pancreatic Cancer;Results;Results;Pre-implant CT scan (Case one) ;Post-implant CT scan ;Pre-implant CT scan (Case Two) ;术后CT扫描;Post-implant CT scan;病例2 男性 76岁 胰腺癌（胰体尾部）;术后CT扫描;Pre-implant CT scan (Case Four) ;Post-implant CT scan;Post-implant CT scan;Complications;Discussion;Technical points during the procedure;Drug-seeds combined therapy;Conclusions;国内临床尚有许多问题需要解决 ;展 望;Thanks for your attention