人类群体遗传学—第二讲资料.ppt

人类群体遗传学基本原理和分析方法 ;序号; 第二讲; 第二讲;Polymorphism;Polymorphism;56 ethnic groups in China;;Human Genetic Diversity;Polymorphism;Sexual dimorphism;DNA polymorphism;Intuitive statistics;Human SNP data;Heterozygosity;Heterozygosity related issues;Population Mutation Rate (q ) ;Estimators of θ;Under the infinite site model, K is equal to the number of mutations since the most recent common ancestor of the sequences in the sample. Therefore, K has a clear biological meaning. However, K depends on the sample size. ;Normalized K ;;The properties of θK;How many common SNPs in human genome?;ThetaK=1.2/kb;Th