糖尿病性周围神经病变早期感觉神经动作电位波幅变化的意义.doc

糖尿病性周围神经病变早期感觉神经动作电位波幅变化的意义 糖尿病患者一旦出现周围神经病变，很难进行有效的修复治疗，因此早期发现和诊断极为重要。中国昆明医科大学第四附属医院王建林博士所带领的团队检测500例糖尿病患者上、下肢感觉和运动神经传导，发现与正常对照者相比，糖尿病患者正中神经、尺神经、胫神经和腓总神经运动和感觉功能减退，且周围神经病变患者的变化更为明显。糖尿病患者中358例患者（71.6％）出现神经传导检查异常，其中腓总神经最为明显，且糖尿病患者感觉神经异常比率较运动神经高，感觉神经动作电位波幅对糖尿病患者周围神经病变最为敏感。结果提示糖尿病周围神经病变患者早期无临床症状阶段即可有不同程度的神经传导特性改变，且感觉神经动作电位波幅可作为糖尿病性周围神经病早期诊断及修复治疗的依据。相关文献发表于《中国神经再生研究（英文版）》杂志2014年7月第14期。 Article: Amplitude of sensory nerve action potential in early stage diabetic peripheral neuropathy: an analysis of 500 cases, by Yunqian Zhang1, Jintao Li2, Tingjuan Wang1, Jianlin Wang1 1 Department of Neurology, the Fourth Affliated Hospital of Kunming Medical University, Kunming, Yunnan Province, China; 2 Neuroscience Institute, Kunming Medical University, Kunming, Yunnan Province, China Zhang YQ, Li JT, Wang TJ, Wang JL. Amplitude of sensory nerve action potential in early stage diabetic peripheral neuropathy: an analysis of 500 cases. Neural Regen Res. 2014;9 14 :1389-1394. 欲获更多资讯：Neural Regen Res Amplitude of sensory nerve action potential in early stage diabetic peripheral neuropathy Early diagnosis of diabetic peripheral neuropathy is important for the successful treatment of diabetes mellitus. Research group at the Fourth Affiliated Hospital of Kunming Medical University, China, led by Dr. Jianlin Wang sought to establish a sensitive index for nerve conduction studies in the early diagnosis of peripheral neuropathy in 500 patients with diabetes mellitus. Nerve conduction studies revealed that distal motor latency was longer, sensory nerve conduction velocity was slower, and sensory nerve action potential and amplitude of compound muscle action potential were significantly lower in the median, ulnar, posterior tibial and common peroneal nerve in the diabetic groups compared with control subjects. Moreover, the alterations were more obvious in patients with symptoms of peripheral neuropathy. Of the 500 diabetic patients, neural conduction abnormalities were detected in 358 cases