华蟾素腹腔热灌注对癌性腹水患者T淋巴细胞亚群影响.pdfVIP

3、两组中医症状积分变化：两组总有效率比较无统计学意义(p0．05)： 4、两组KPS评分变化：两组有效率比较无统计学意义(p0．05)； 5、安全性指标评价：两组治疗中均未出现发热、心电图及肾功能改变情况；奈 达铂组出现因药物引起的骨髓抑制、肝功异常；两组均出现疼痛、呕吐及腹泻的不良 反应；其中两组腹痛及腹泻发生率分别比较差异均无统计学意义(p0．05)；呕吐发 生率差比较差异有统计学意义(p0．05)。 结论： 1、华蟾素腹腔热灌注疗法对晚期恶性肿瘤患者T淋巴细胞亚群有明显影响，对 CD3+、CD4+、CD4+／CD8+细胞比例可提高，CD8+细胞比例降低，可提高患者机体免疫功 能，从而间接增强抗肿瘤作用： 2、华蟾素腹腔热灌注疗法对癌性腹水肿瘤标志物水平有显著降低作用，可能与华 蟾素注射液抗肿瘤作用及热效应可提高药物抗癌活性及敏感性有关； 3、华蟾素腹腔热灌注疗法可延缓癌性腹水的生长，总有效率60％，控制效果较好； 4、华蟾素注射液腹腔热灌注对腹腔局部压迫症状改善显著，患者中医常见症状得 以有效缓解，且KSP评分也明显提高： 5、华蟾素腹腔局部热灌注，药物直达病所，可明显改善局部“湿毒证”； 6、华蟾素腹腔热灌注疗法毒副反应少，患者耐受性较好，值得临床推广。 关键词：癌性腹水；华蟾素注射液：腹腔热灌注；T淋巴细胞亚群；腹水肿瘤标志物 II Effect of Cinobufacini injection hyperthermiC intraper itoneaI on T——I ymphocyte subsets i n pat i ents w i th ma I i gnant asc i tes Abstract Objective Malignant ascites is one of the colmllon complications in some tumors，and is a sign of disease progression and poor prognosis．Patients happen abdominal distention，magersucht and poor appetite，causing great pain to patients，not only lower the quality of 1ife，and shorten the lifetime．There are SO many methods to treatment，but the report that patients can be effectively controlled to malignant ascites and improved symptoms on the premise of the tolerance is not much．Anticancer Chinese medicine injections is research and development in recent decades，it besides has anti—cancer effect and also can improve the body’S immune function，improve patients’life quality，and have a litter of toxic and side reaction．Now Cinobufacini injection is one of the most explicit anticancer Chinese medicine injections，and joint hyperthemal perfusion therapy to treating malignant ascites．Through observing the clinical efficacy and the security index，possible mechanism of action is discussed．The treatment of malignant ascites may expand some new ways to provide beneficial information． Methods The case source of topic is from the patients，selectted and accorded with inclusion criteria of the topic，that had cancer with malignant ascites at the tumor medical ward of Hospitals