研究生专业英语要点.pptVIP

GLUT2 lowest affinity for glucose, also transport fructose liver, pancreatic islet cells, retina, stomach overexpression in gastric tumors was not detected in insulinomas or other types of islet cell tumors GLUT3 overexpression in many tunors brain, placenta, testes means poor prognosis highest affinity for glucose and insensitive to insulin GLUT4 cardiac muscle, skeletal muscle, adipose overexpression in gastric and breast cancer GLUT5 kidneys, testes, small intestine, muscle, adipose tissue overexpression in renal cell carcinoma, breast and prostate cancer high affinity for glucose and sensitive to insulin high affinity for fructose GLUT8 testis, adrenal gland, liver, spleen and lung. overexpression in multiple myeloma GLUT12 overexpression in breast cancer heart, small intestine, skeletal muscle Factors regulating expression of GLUTs, HK2, PFK1, PKM2 1. hypoxia 2. oncogene and tumor supressor gene C-myc p53 3. growth factors EGF 4. hormones estrogen hypoxia-inducible factor-1, HIF-1 HIF-1β HIF-1α stable prolyl hydroxylases (PHDs) hydroxylation O2 + transcription of target genes GLUT1 GLUT3 HK2 PDK1 LDHA PKM2 hypoxia SCI: Science Citation Index Institute for Scientific Information 3500 Impact factor 10.165 人类生殖学新资讯 Hum. Reprod. Update Human reproduction update 11.055 肝脏病学 Hepatology Hepatology (Baltimore, Md.) 12.515 实验医学杂志 J. Exp. Med. The Journal of experimental medicine 12.583 国立癌症研究所杂志 J. Natl. Cancer Inst. Journal of the National Cancer Institute 13.938 欧洲泌尿科学 Eur. Urol. European urology 18.428 临床肿瘤学杂志 J. Clin. Oncol. Journal of clinical oncology : official journal of the American Society of Clinical Oncology 23.523 癌细胞 Cancer cell Cancer cell 24.69 柳叶刀：肿瘤学 Lancet Oncol. The lancet oncology 37.4 自然评论：癌症 Nat. Rev. Cancer Nature reviews. Cancer 115.84 癌 CA Cancer J Clin CA: a cancer journal for clinicians 影响因子 中文译名 缩写 杂志全称 6.393 人类分子遗传学 Hum. Mol. Genet. Human molecular genetics 6.667 流行病学评论 Epidemiol Rev Epidemiologic reviews 7.04 肿瘤学纪事 Ann. Oncol.