放疗致痛单中心调查-金晶教程方案.ppt

For prevention: Suggest tooth brushing, flossing and ≥ 1 month rinses to maintain oral hygiene. Against using chlorhexidine mouth wash. For treatment: No guideline available regarding basic oral care No guideline available regarding role of using mouth rinses: saline, sodium bicarbonate, mixed medication mouthwashes, calciumphosphate, and chlorhexidine. Guideline: The Panel suggests using oral care protocols in the prevention of oral mucositis in all age groups and across all cancer treatment modalities. No guideline was possible for the use of oral care protocols in the treatment of oral mucositis in any population due to insufficient and/or conflicting evidence. 醋酸洗必泰0.08%（w/w）、薄荷Herba Menthae. 0.5%-1%（w/w）、杭白菊Flos Chrysanthemi 6.5%（w/w）、金银花HoneysuckleFlower6%-8%（w/w）。 [2, 4, 6, 10–13, 15, 17, 25, 28–31, 41, 43, 45, 56, 57, 59,60, 66, 67, 70]. Prevention主要研究终点：粘膜炎的发生率、放声时间、高峰时间、细菌和霉菌感染率等 不建议应用的原因主要是对味觉影响， * 金因肽：活性成份为重组人表皮生长因子（rhEGF）。以10%的甘油和1.0的甘露醇为保护剂。 Due to inadequate and=or conflicting evidence, no guideline was possible for the following agents reviewed: palifermin and granulocyte-macrophage–colony-stimulating factor in treatment settings other than that listed above, fibroblast growth factor-20, keratinocyte growth factor-2, granulocyte–colony-stimulating factor, transforming growth factor-b, epidermal growth factor, milk-derived growth factor extract, interleukin-11, ATL-104, and recombinant human intestinal trefoil factor.23 (at a dose of 60 lg/kg per day for 3 days prior to conditioning treatment and for 3 days after transplant) G-CSF has been associated with reduced local tumor control during HNRT. * 苄达明;消炎灵 ，炎痛静,盐酸苄达明，祛炎痛 Difflam喉咙喷雾 米索前列醇前列腺素E类似物，粘膜保护 * Acyclovir阿昔洛韦, clarithromycin克拉霉素, Nystatin制霉菌素, kefir（牛奶发酵物，酸奶）, ， 聚维酮碘，氟康唑， 透明质酸钠外用，丁卡因，达克罗宁，MGI??-209（与苯佐卡因），可卡因，丁卡因，辣椒素，美沙酮，氯胺酮，去甲替林和加巴喷丁。povidone-iodine, fluconazole, sodium hyaluronate topical, tetracaine, dyclonine, MGI- 209 (with benzocaine), cocaine, amethocaine, capsaicin, methadone