神经生物学2离子通道和神经元的电活动.pptVIP

Functional properties of the sodium channel (Na+ 通道的功能) They open with little delay They stay open for about 1 ms and then close (inactivate) They cannot be opened again by depolarization until the membrane potential returns to – 65 mV 关闭 开放 失活 去失活 Functional properties of the sodium channel (c) A model for how changes in the conformation of the sodium channel protein might yield its functional properties. The closed (关闭) channel; Opens (开放) upon membrane depolarization; Inactivation (失活) occurs when a globular portion of the protein swings up and occludes the pore; Deinactivation (去失活)