传统和非传统的心血管风险因素关系冠状动脉钙在型糖尿病.docVIP

Relationship of Traditional and Nontraditional Cardiovascular Risk Factors to Coronary Artery Calcium in Type 2 Diabetes Theodore Mazzone1, Peter M. Meyer2, George T. Kondos3, Michael H. Davidson4, Steven B. Feinstein4, Ralph B. D’Agostino, Sr.5, Alfonso Perez6, and Steven M. Haffner7 1 Department of Medicine, Section of Endocrinology, Diabetes and Metabolism, University of Illinois College of Medicine, Chicago, Illinois2 Department of Preventive Medicine, Rush University Medical Center, Chicago, Illinois3 Department of Medicine, Section of Cardiology, University of Illinois College of Medicine, Chicago, Illinois4 Department of Medicine, Section of Cardiology, Rush University Medical Center, Chicago, Illinois5 Department of Mathematics, Statistics and Consulting Unit, Boston University, Boston, Massachusetts6 Takeda Global Research and Development, Lincolnshire, Illinois7 Department of Medicine, University of Texas Health Science Center, San Antonio, Texas Address correspondence and reprint requests to Theodore Mazzone, MD, Section of Diabetes and Metabolism (MC 797), University of Illinois at Chicago, 1819 W. Polk St., Chicago, IL 60612. E-mail: tmazzone@ Abbreviations: apo, apolipoprotein; CAC, coronary artery calcium; CACS, coronary artery calcium score; sBP, systolic blood pressure; TAT, total abdominal adipose tissue; TRL, triglyceride-rich lipoprotein; VAT, visceral adipose tissue; WHR, waist-to-hip ratio  ?? ABSTRACT TOPABSTRACTRESEARCH DESIGN AND METHODSRESULTSDISCUSSIONNOTE ADDED IN PROOFREFERENCES ?We evaluated correlates of coronary atherosclerosis, measured by coronary artery calcium, in a racially diverse group of male and female subjects with type 2 diabetes. Age, systolic blood pressure, sex, and race/ethnicity were significant determinants of coronary artery calcium. Among lipoproteins, cholesterol level contained in a particle excluded from direct measures of LDL and HDL cholesterol (designated triglyceride-rich lipoprotein ch