浅析血清中AFP,AFU,γGT联合检测的临床意义(精选).docVIP

浅析血清中AFP，AFU，γ-GT联合检测的临床意义 Significance of Combined Detection of AFP,AFU,and γ-GT in the Serum of Liver Cancer Patients 姚 涛 YAO Tao 长沙市传染病医院检验科 中国 410011 Chang Sha City Hospital For Infectious Disease 中图分类号：R496.11+2 文献标识码：A 文章编号：1818－0086（2009）03 摘 要:目的 研究3种血清检测指标对原发性肝癌诊断的临床意义，以提高对原发性肝癌检测的敏感性。 取原发性肝癌患者50例，肝硬化患者50例， 其它恶性肿瘤患者50例， 健康志愿者60例血清，应用放射免疫法（RIA）检测AFP（甲胎蛋白），速率法检测AFU（a-l岩藻糖甘酶）,γ-GT（谷胺酰转肽酶）。 原发性肝癌各项指标与其它恶性肿瘤组，肝硬化组比较三项都有明显差异。原发性肝癌组单项AFP，AFU，γ-GT阳性检出率分别是74%，64%，68%。AFP，AFU，γ-GT诊断符合率分别是81%，84%，79%。联合检测敏感性达96%，与单项AFP（74%）检测敏感性有显著差异（P〈0.01）。 联合测定AFP，AFU，γ-GT可提高对原发性肝癌的阳性诊断率。 甲胎蛋白；原发性肝癌；肿瘤标志物 The clinical significance of the diagnosis of primary hepatic cancer through the detection results of there kinds of serum was studied,and the sensitivity in primary hepatic cancer was improved. Methods AFP,AFU and γ-GT in the serum of liver cancer patients 50 ,cirrhosis patients 50 ,malignant thumor patients 50 and healthy volunteers 60 were determihated respectively by RIA and rate method.There were obvious difference of AFP,AFU and γ-GT between the primary hepatic cancer patients group and cirrhosis patients group,malignant tumor patients groups. Results The positive detection rate of AFP, AFU and γ-GT were respectively 74%,64% and 68% in primary hepatic cancer patients group. The rate of definitive diagnosis were respectively 81%,84% and 79%. There was obvious different of the sensitivity between the combined detection 96% and the AFP individual detection 74% . The signiticance of difference was obvious p 0.01 . Conclusion The positive rate of primary hepatic cancer was immproved by combined detection of AFP,AFU and γ-GT. Key words： Alpha-fetoprotein； Primary hepatic cancer； Tumor marker 原发性肝癌及时与准确的诊断，关系到患者能否得到正确而及时的治疗。第四届肝癌学术会议通过了新的肝癌诊断标准,其中就有提到肿瘤标志物的联合检测。这在临床工作中是对肝癌诊断的进步与完善。此文就AFP,AFU 和 γ-GT三种血清肿瘤标志物检测的敏感性，降低肝癌的漏诊率作初步探讨。 1.1 对象 病例均选自我院1999年2月~2007年12月收治的部分住院病人。 1.2 选择标准 所有病例均为“B超”影像学和病理组织检查确诊。 1.3 分组 1.3.1 原发性肝癌50例,男41例,女9例,年龄37~76,平均