温州地区成人呼气峰流速日变异率波动范围.docVIP

温州地区成人呼气峰流速预计值及与其他国家比较 中南大学湘雅医院 摘要：目的：为提高温州地区哮喘患者的诊断准确率，更加有效地治疗及管理哮喘，初步建立温州地区正常成年人呼气峰流速预计值，探讨其与其他预计值相关性。方法：选取温州医科大学附属第二医院2012年6月至2013年1月正常体检人群70人。用微型峰流速仪每人站立测3次或3次以上，取最大值，操作按照《支气管哮喘防治指南》进行。详细记录去鞋身高，少衣体重及性别、年龄等。结果：呼气峰流速随着身高、体重的增加而增加，随着年龄的增加而减少。将身高和年龄纳入方程，新预计值公式为男性PEF（L/min）=-81.798+1.326*age-0.024*age2+4.015*height（R2=0.233 SD=81.97）女性（L/min）=161.482+0.65*age-0.028*age2+3.779height。（R2=0.278 SD=62.33）。按照新预计值公式所得呼气峰流速与传统公式所得呼气峰流速差异均有统计学意义。新预计值公式所得值要大于传统公式所得结果。新预计值公式结果低于英国、斯里兰卡、地中海等地预计值，但是高于土耳其和尼日利亚所得预计值。差异有统计学意义。实测值占预计值80%与呼气峰流速日变异率20%在诊断哮喘方面诊断价值相似。曲线下面积分别为（0.629、0.652）敏感性分别为（64.8、67.7）特异性分别为（84.6、78.2）阳性预测值分别为（97.2、88.6）阴性预测值分别为（22.7、23.9）不同峰流速实测值占预计值比例对不同程度的气流受限有不同的诊断价值。PEF60%pred能筛选出100%的重度气流受限患者。结论：温州地区人群预计值公式不同于中国现使用预计值公式。各地区需要建立本地区适宜的呼气峰流速预计值公式。呼气峰流速占预计值80%有和呼气峰流速日变异率20%相同的诊断价值。呼气峰流速占预计值百分比可用来筛查哮喘早期气流受限患者。 Abstract：Objective: For effective asthma diagnosement and management in wenzhou adults, we established reference ranges for the PEFR in adults in Wenzhou city. Discuss the relevance between it with other reference ranges at the same time. Methods:seventy people who do physical examination were collected from section for outpatients of the second affiliated hospital of wenzhou medical university dating from June.2013 to Jan.2013.every person has to take the peak expiratory flow rate test with the Mini Wright Peak Flow Meter (MWPFM). Everyone should try at least three times,then take the maximum value. All tests were conducted using a Standardized method recommended by the Guide?for?Prevention and Treatment?of?BronchialAsthma.Records the height without shoes, weight ,gender, age, etc at the same time.Results:The PEFR increased with height, weight.But reduces with age. There was significant difference between the measured values and the expected values of female and male population.The results of new formulation were lager than that of old formulation. There were also significant differences between new expected values and other countries re