有机课件5-卤代烃.pptVIP

 2.9.1 Characteristics of the E2 Reaction ——The E2 Reaction Stereochemistry Predict the product: Abstracted proton and leaving group should align trans-diaxial to be anti periplanar (app) in approaching transition state Elimination From Cyclohexanes The more steric hindrance, the weaker nucleophiles: 位阻越大亲核性越小 5.8.1 Characteristics of the SN2 Reaction ——Nucleophiles In general: 5.8.1 Characteristics of the SN2 Reaction ——Leaving Groups 离去基团 A good leaving group reduces the barrier to a reaction 有利于反应的进行 Stable anions that are weak bases are usually excellent leaving groups