齐都药业硫辛酸胶囊价格对糖尿病周围神经病变治疗效果的影响(精选).docVIP

:? Could you talk about the recent advance in the management of diabetic peripheral neuropathy 《国际糖尿病》：糖尿病周围神经病变治疗上？ Prof.Zeigler:?There have been some new drugs developed over the past two decades as well as other drugs around derived from the pathogenesis of diabetic peripheral neuropathy.? So far， with the exception of aldose reductase inhibitors， which as been a power stud and is marketed in Japan and India， there are few drugs available.? One drug， alpha lipoic acid， reduces oxidative stress and has been shown to improve diabetic neuropathy， including both symptoms and impairment resulting from that condition. Zeigler教授:?过去20年中，在这个领域出现了一些新的药物，其中一部分是源自对糖尿病周围神经病变发生的病因学认识的。但迄今为止除了醛糖还原酶抑制剂的作用效果确切，已在日本和印度上市销售以外，市面上可选择的药物很少。其中一种叫做a-硫辛酸的药物可以抑制氧化应激，并且研究显示其具有改善糖尿病神经病变的作用，包括临床症状和氧化应激造成的损害等方面的改善。 :?What are some of the modifiable risk factors for diabetic peripheral neuropathogenesis 《国际糖尿病》：糖尿病周围神经病变病因学方面有哪些可改变的危险因素？ Prof.Zeigler:?We performed population based epidemiological studies to look at the risk factors for polyneuropathy in both diabetic and pre-diabetic patients.? We found that， in particular， the risk factor that emerged was visceral obesity， which is of course modifiable by life style modification and weight loss induction.? This is a major new finding for the field of neuropathy.? Other studies have found that hyperlipidemia is another modifiable risk factor.? Although one can’t do anything about age， which is another important risk factor.? The most important comorbidity is peripheral arterial disease， which can also be prevented and treated.? Studies from the United States have shown that hypertension， a modifiable cardiovascular risk factor， has been associated with diabetic peripheral neuropathy.? So you can see that it is basically a component of metabolic syndrome which are modifiable and simultaneously risk factors of diabetic peripheral neuropathy. Zeigler教授:?为了观察糖尿病和糖尿病前期患者中与多神经病变相关，我们开展了基于人群的流行病学研究。发现其中一个特别重要的危险因素就是腹型肥胖，当然这个危险因素是可以通过生活方式改善和减重来改变的。