pet_spect.pptVIP

Drug Delivery Tumors do not have a blood tumor barrier Image removed. Delivery Strategies: Metabolic pathways Delivery Strategies: Metabolic pathways Glu →G6P→ F6P→FBP ?FDG is transported into the cells ?FDG is phosphorylated to FDG-6P (charged molecules cannot diffuse out) ?FDG is NOT a substrate for the enzyme that catalyzes the next step in glycolysis.. Image removed Mapping Human Brain Function 18F-FDG PET scans show different patterns of glucose metabolism related to various tasks. Image removed. FDG in Oncology ? FDG transport into tumors occurs at a higher rate than in the surrounding normal tissues. ? FDG is de-phosphorylated and can then leave the cell. ? The dephosphorylation occurs at a slower rate in tumors. Applications of FDG ?Locating unknown primaries ?Differentiation of tumor from normal tissue ?Pre-operative staging of disease (lung, breast, colorectal, melanoma, HN, pancreas) ?Recurrence vs necrosis ?Recurrence vs post-operative changes (limitations with FDG) ?Monitoring response to therapy Delivery Strategies: Metabolic pathways PET can provide highly specific metabolic information. ? FDG, MET, FLT are incorporated via transporters ? Uptake is indicative of tumor grade. 11C-methionine ?specific for tumor ?avoids high brain background problem seen with FDG ?no significant uptake in chronic inflammatory or radiogenic lesions ?MET better than FDG in low-grade gliomas Functional imaging of gliomas Imaging objectives ? Location and relation to surrounding brain activity ? Biological activity = malignancy ? Response to therapy Image removed. Tumor recurrence vs post-radiotherapy changes FDG uptake indicates Recurrence Left: MRI Center: PET Right: fused image Image removed. Functional Imaging Tumor vs functional brain 11C-MET + MRI delineates tumor (GREEN) [15O]H2O