酯化以及酰胺化.docxVIP

A 300-mL, one-necked, round-bottomed flask was equipped with a magnetic stirrer, Dean-Stark trap, and a reflux condenser. The flask was charged with 3.0 g (20 mmol) of L-(+)-tartaric acid, 6.5 g (60 mmol) of benzyl alcohol, 47.5 mg (0.25 mmol) of p-toluenesulfonic acid monohydrate and 40 mL of toluene. The mixture was heated under reflux in an oil bath (about 130℃) for 13 h. During this period the theoretical amount of water (0.62 mL) was collected. The mixture was allowed to cool to ambient temperature, diluted with ether, and poured into 50 mL of aqueous, saturated sodium bicarbonate. The or