复发性风湿症患者不良预后的影响因素的研究.docVIP

复发性风湿症患者不良预后的影响因素的研究 【摘要】 目的：了解抗环瓜氨酸肽（CCP）抗体及发作频率对复发性风湿症（PR）患者发展为类风湿关节炎（RA）的影响。方法：分析2010年1月-2015年1月本院收治的复发性风湿症患者的临床及实验室资料，按照患者就诊时CCP检查结果分为CCP抗体阳性组5例，阴性组18例；按患者发作频率分为高频率发作组（发作频率≥12次/年）7例，低频率发作组（发作频率0.05）；高频率发作组中3例发展为RA（42.9%）；低频率发作组均未发展为RA。高频率发作组发展为RA的患者比例高于低频率发作组，比较差异有统计学意义（P 0.05）。结论：高频率发作的复发性风湿症患者发展为RA的风险高于低频率发作的患者，这部分患者需要更积极的治疗干预。CCP抗体对复发性风湿症是否发展为RA的意义待定。 【关键词】 复发性风湿症； 抗环瓜氨酸肽抗体； 发作频率 Research on the Influence Factors of Poor Prognosis in Patients with Recurrent Rheumatism/WEN Yan-fang，CHEN Jian-feng，LIAO Xiang-ping，et al.//Medical Innovation of China，2016，13（10）：004-007 【Abstract】 Objective：To study whether the attack frequency and anti-cyclic citrullinated peptide（CCP） antibodies are risk factors for patients with palindromic rheumatism（PR） progressed to rheumatoid arthritis（RA）.Method：Twenty-three patients with PR from January 2010 to January 2015 were selected and devided into 5 patients of positive CCP group and 18 patients of negative CCP group，7 patients of high attack frequency group（attcks≥12 times per year） and 16 patients of low attack frequency group（attcks0.05）.Three patients developed to RA in the high attack frequency group（42.9%） and none in the low attack frequency group，the proportion of patients developing into RA in the high attack frequency group was higher than that in the low attack frequency group，the difference was statistically significant（P 0.05）.Conclusion：The probability of developing to RA in patients with high attack frequency PR is higher than that in patients with low attack frequency，patients with high attack frequency PR need more active treatment intervention.The meaning of CCP antibodies for PR developing to RA is still to be determined. 【Key words】 Palindromic rheumatism； Anti-cyclic citrullinated peptide antibodies； Attack frequency First-author’s address：The First People’s Hospital of Chenzhou City，Chenzhou 423000，China 　　doi：10.3969/j.issn.1674-4985.2016.10.002 复发性风湿症（palindromic rheumatism，PR），又称为回纹型风湿症，最早由Hench等[1]于1944年