清热透疹方用于普通型手足口病的临床疗效.docVIP

清热透疹方用于普通型手足口病的临床疗效 　　[摘要] 目的 探讨清热透疹方应用于普通型手足口病（HFMD）治疗的临床效果及安全性。 方法 选取2014年3月～2015年6月广州市花都区妇幼保健院收治的普通型HFMD患儿100例，应用随机数字表法分为观察组与对照组，各50例。对照组患儿在常规治疗基础上给予利巴韦林注射液治疗，观察组患儿在常规治疗基础上给予清热透疹方治疗。观察两组患儿治疗效果、主要临床体征和症状消退时间；观察治疗期间不良反应发生情况；比较两组患儿治疗前后心肌损伤情况。 结果 观察组患儿总有效率为98%，对照组患儿总有效率为82%，观察组有效率明显高于对照组，差异有高度统计学意义（P 0.01）；与对照组比较，观察组患儿皮疹消退时间、发热消退时间、心肌酶恢复时间、白细胞恢复时间、胸片吸收时间均显著缩短，差异均有统计学意义（P 0.05）；与对照组比较，观察组患儿咳嗽消退时间、呕吐消退时间及大便干结消退时间均显著缩短，差异均有统计学意义（P 0.05）；与治疗前比较，观察组患儿LDH、CK、CK-MB及HBNH水平均显著降低，差异均有统计学意义（P 0.05）；治疗后，与对照组比较，观察组患儿心肌损伤情况也显著改善，差异有统计学意义（P 0.05）。 结论 清热透疹方用于治疗普通型HFMD具有显著的效果，能快速缓解患儿症状，安全性高，使患儿早日康复，缩短住院时间，降低医疗费用，减轻家庭经济负担，值得临床推广。 　　[关键词] 清热透疹方；中医；手足口病；清热解毒；透疹凉血 　　[中图分类号] R512.5 [文献标识码] A [文章编号] 1673-7210（2016）04（a）-0100-04 　　[Abstract] Objective To discussion the efficacy and safety of Qingre Touzhen Formula in the treatment of common type of hand， foot and mouth disease （HFMD）. Methods From March 2014 to June 2015， 100 cases of common HFMD in Huadu District Maternal and Child Health Care Hospital of Guangzhou were selected， they were divided into observation group and control group by random number table method， 50 cases in each group. Children in the control group were given ribavirin injection based on the conventional treatment， and the observed group was given Qingre Touzhen Formula based on the conventional treatment. The treatment effect， the main clinical signs and symptoms subsided time of the two groups was observed； the adverse reactions occurred during the treatment were observed； myocardial injury before and after treatment of the two groups was compared. Results The total effective rate of the observation group was 98%， and the control group rate was 82%， the observation group was significantly higher， the difference was statistically significant （P 　　[Key words] Qingre Touzhen Formula； Chinese Medicine； Hand， foot and mouth disease； Clearing away heat and toxin； Touzhen cooling 　　手足口病（hand-foot-mouth disease，HFMD）是儿童人群中常见的传染性疾病，具有较强的传染性，由一种肠道病毒感染疾病，引发HFMD