瑞舒伐他汀联合复方丹参治疗冠心病合并高胆固醇血症患者的效果及其对载脂蛋白A1、载脂蛋白B和脂蛋白酯酶水平的影响.docVIP

瑞舒伐他汀联合复方丹参治疗冠心病合并高胆固醇血症患者的效果及其对载脂蛋白A1、载脂蛋白B和脂蛋白酯酶水平的影响 　　[摘要] 目的 探讨瑞舒伐他汀联合复方丹参治疗冠心病合并高胆固醇血症患者的效果及其对载脂蛋白A1（ApoA1）、载脂蛋白B（ApoB）和脂蛋白酯酶水平的影响。 方法 选取2011年3月～2015年6月四川省人民医院崇州分院诊治的82例冠心病合并高胆固醇血症患者为研究对象，根据治疗方案的不同分为瑞舒伐他汀组（单独组）和瑞舒伐他汀+复方丹参组（联合组），每组各41例，比较两组心功能、血脂、氧化指标、六分钟步行试验阳性率、ApoA1、ApoB和脂蛋白酯酶水平。 结果 联合组治疗后的血脂指标均明显降低（P 0.05）。两组治疗后心输出量（CO）和左室射血分数（LVEF）明显升高（P 0.05）；联合组治疗后CO和LVEF的增加幅度明显优于单独组（P 0.05）。联合组治疗后氧化型低密度脂蛋白（ox-LDL）、丙二醛（MDA）、超氧化物歧化酶（SOD）及ApoA1、ApoB和脂蛋白酯酶水平的改善程度均较单独组明显（P 0.05）。 结论 瑞舒伐他汀联合复方丹参可提高冠心病合并高胆固醇血症的临床疗效，改善患者心功能，降低血脂、ApoA1、ApoB和脂蛋白酯酶水平。 　　[关键词] 瑞舒伐他汀；复方丹参；冠心病；高胆固醇血症 　　[中图分类号] R541.4 [文献标识码] A [文章编号] 1673-7210（2016）03（a）-0123-04 　　Effect of Rosuvastatin combined with Danshen Compound in the treatment of coronary heart disease with hypercholesterolemia and influence on the levels of ApoA1， ApoB and lipoprotein lipase 　　LIU Yao LI Junfeng WANG Anwei ZHANG Yaxi GAO Jinquan 　　Department of Cardiology， Chongzhou Branch of Sichuan Provincial People′s Hospital， Sichuan Province， Chongzhou 611230， China 　　[Abstract] Objective To explore effect of Rosuvastatin combined with Danshen Compound in the treatment of coronary heart disease with hypercholesterolemia and influence on the levels of ApoA1， ApoB and lipoprotein lipase. Methods 82 cases of coronary heart disease with hypercholesterolemia from March 2011 to June 2015 at Chongzhou Branch of Sichuan Provincial People′s Hospital were selected as research objects. The patients were randomly divided into two groups according to different treatment regimens： Rosuvastatin group （single group） and Danshen Compound plus Rosuvastatin group （combined group）， each group had 41 cases. The cardiac function， blood lipids， oxidative indexes， 6 minutes walk test positive rate， ApoA1， ApoB and lipoprotein lipase levels were compared between two groups. Results After treatment， the serum lipids indicators were significantly decreased in combined group （P 0.05）. After treatment， cardiac output （CO） and left ventricular ejection