利多卡因晨课详解.pptVIP

利多卡因临床非麻醉用途 张伟义 　利多卡因为酰胺类局麻药,对中枢神经系统有明显的兴奋和抑制双相作用,且可无先驱的兴奋,血药浓度较低时,出现镇痛和思睡、痛阈提高;随着剂量加大,作用或毒性增强,亚中毒血药浓度时有抗惊厥作用;当血药浓度过高时又可发生惊厥。 低剂量时可促进心肌细胞内K+外流,降低心肌的自律性,而具有抗室性心律失常作用。血药浓度进一步升高,可引起心脏传导速度减慢,房室传导阻滞,抑制心肌收缩力和使心排血量下降。 用于预防气管插管引起的咳嗽 Intravenous Lidocaine as a Suppressant of Coughing during Tracheal Intubation ANESTH ANALG 1985;M: 1189-92 麻醉专业 Intravenous Lidocaine as a Suppressant of Coughing during Tracheal Intubation ANESTH ANALG 1985;M: 1189-92 Intravenous Lidocaine as a Suppressant of Coughing during Tracheal Intubation ANESTH ANALG 1985;M: 1189-92 用于预防芬太尼诱导引起的咳嗽反射 Intravenous lidocaine and ephed