DGAVersion1.0Prototype.ppt

DGAVersion1.0Prototype.ppt

生物信息学 及其软件平台 第一部分: 生物信息学研究需要什么? 需要什么? 数据库(DNA、蛋白质序列) 各种算法(Blast, Genscan……) 这样就行了吗? ——用户(生物学研究人员)如何能更好的使用a和b Bioinformatics – a Definition --Oxford English Dictionary (Molecular) bio – informatics: bioinformatics is conceptualising biology in terms of molecules (in the sense of Physical chemistry) and applying “informatics techniques” (derived from disciplines such as applied maths, computer science and statistics) to understand and organise the information associated with these molecules, on a large scale. In short, bioinformatics is a management information system for molecular biology and has many practical applications. Bioinformatics: 科技界一颗耀眼的新星 在BIOINFORMATICS 没有诞生之前, 一个新药的问世需要十年时间,数亿美元的RD,而BIOINFORMATICS已将这个过程减少三分之二,RD的费用也相应大大减少。许多中小BIOTECH 公司也看到了BIOINFORMATICS 的巨大作用和潜在的商机,纷纷投资BIOINFORMATICS研究项目。 美国电脑执照--高薪阶层 “BIOINFORMATICS CERTIFICATION”,这是目前最新的一门生物化学工程与电脑技术相结合的课程。包括“CBS”证书和“CBM”证书。 Visual Basic????? -- $1195 Visual  C + +????????????????? -- $1295 BioInformatics? -- CBS, CBM?? $2500 MIT: Course: 20.01s Date: June 24 - 28, 2002 Tuition: $2,500 后基因组时代 Pic5 Pic6 Pic7 Major Application I:Designing Drugs Understanding How Structures Bind Other Molecules (Function) Designing Inhibitors Docking, Structure Modeling Major Application II: Finding Homologs Major Application III: Overall Genome Characterization Overall Occurrence of a Certain Feature in the Genome e.g. how many kinases in Yeast Compare Organisms and Tissues Expression levels in Cancerous vs Normal Tissues Databases, Statistics proteomics data Proteomics tools Identification and characterization DNA - Protein Similarity searches Pattern and profile searches Post-translational modification prediction Primary structure analysis Secondary structure prediction Tertiary structure Transmembrane regions detection Alignment CIF:生物信息学构架 Corporate Information Factory(CIF)是一个支援企业级的信息系统构架结构。生物信息学是在生物研究中信息系统的应用。CIF正是一个从不同的源头来集成生物信息学数据,数据库中管理这些信息,并将这些信息递交专家系统进行处理的一个完整的体系,数据集成、数据标准化、数据完

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