80例Ⅰb2～Ⅳa期宫颈鳞癌患者两种含铂化疗方案的疗效和安全性分析.docVIP

80例Ⅰb2～Ⅳa期宫颈鳞癌患者两种含铂化疗方案的疗效和安全性分析 【摘要】目的：探讨Ⅰb2～Ⅳa期宫颈鳞癌患者同步放化疗中两种含铂化疗方案的疗效和安全性。方法：病例选自2010年2月至2013年4月我院的80例Ⅰb2～Ⅳa期宫颈鳞癌的患者。在患者知情同意的情况下，按照随机数表法，将所有患者均分为观察组和对照组。对照组采用顺铂同步放疗的方案对患者进行治疗，观察组则采用氟尿嘧啶联合顺铂化疗同步放疗的方案对患者进行治疗。治疗后，评定分析两组患者的近期疗效和不良反应，并随访调查患者的远期疗效。结果：治疗3个月后，发现观察组治疗的总有效率为8500%，对照组的总有效率为7750%，观察组患者总有效率明显高于对照组（P 005）。随访调查3年后，发现观察组患者的3年生存率（8750%）明显高于对照组（6750%），两组比较有统计学意义（χ2 45878，P 00322）；局部复发率和远处转移率（2000%；1750%）均明显低于对照组（4250%；3750%），两组比较有显著性差异（P 005）。结论：氟尿嘧啶联合顺铂化疗同步放疗的方案治疗Ⅰb2～Ⅳa期宫颈鳞癌患者疗效显著，安全性高，值得临床推广应用。 【关键词】宫颈鳞癌；同步放化疗；顺铂；氟尿嘧啶 The efficacy and safety of 80 patientswithⅠ b2 ～ Ⅳa squamous carcinoma of the cervix after receiving two platinum-containing chemotherapy regimensLIAO Dan， YOU Gongping， WU Jinsheng. Department of Obstetrics and Gynecology， Hainan Province Nongken Nada Hospital， Danzhou 571700， China 【Abstract】Objectives： To investigate the efficacy and safety of two platinum-containing chemotherapy regimens to patients with Ⅰb2 ～ Ⅳa squamous carcinoma of the cervix. Methods： 80 patients with Ⅰb2 ～ Ⅳa squamous carcinoma of the cervix in our hospital from February 2010 to April 2013were studied. With patients’ informed consent， all the patients were divided into observation group and control group according to a random number table method. The control group was treated with concurrent radiotherapy and cisplatin and the observation group received fluorouracil and cisplatin combined with concurrent radiotherapy treatment. After treatment， the short-term efficacy and adverse reactions of the two groups were compared， and long-term outcome was followed up. Results： After 3 months， the total effective rate of the observation group and control group was 85.00% and 77.50% respectively， with significant difference （P 005）. After 3 years of follow-up， the 3-year survival rate of the observation group （87.50%） was significantly higher than the control group （67.50%）， with statistically significant difference （χ2 4.5878， P 00322）； the local recurrence rate and distant metast